Titel | Impact of a switch to preservative free Dorzolamide-Timolol on ocular surface disease symptoms |
Doel | To study the impact of a switch from a preserved to preservative free dorzolamide-timolol fixed combination (Cosopt® unit dose) on ocular surface symptoms self-reported by patients. |
Methodes | An 8-week multi-centre, prospective, observational study including glaucoma patients who were switched from a preserved glaucoma eye drop drug to unpreserved dorzolamide-timolol. The Glaucoma Symptom Scale items (GSS functional, symptom and total scores; 0 to 100, the higher the better) were completed by patients at baseline, week 4 and 8. Pairwise t-tests were used for changes from baseline in this interim analysis. |
Resultaten | 77 patients were included (66.5 years; 36% male) and 55 reached week 8 at the time of the interim analysis. GSS total score improved from 65.1 (baseline), to 76.8 (week 4) and 79.9 (week 8; P<0.0001). Respective baseline, week 4 and 8 average scores were 60.0, 74.6 and 78.7 (P<0.0001) for the GSS symptom score and 72.9, 80.3 and 81.6 (P<0.006) for the GSS functional score. All the OSD symptoms had a decrease in prevalence: burning from 72.7% to 50.9%, tearing from 49.4% to 34.6%, dryness feeling from 63.6% to 34.6%, itching from 54.6% to 21.8%, soreness from 50.7% to 41.8% and foreign body sensation from 62.3% to 34.6%. No other adverse events were spontaneously reported. |
Conclusie | This observational survey demonstrated that, in daily practice, a switch to preservative free dorzolamide-timolol fixed combination, improves significantly patient self reported symptoms related to ocular surface disease. All GSS scores had improved at week 4 and even more at week 8. A final analysis on the total study patient population will be available and presented at the OB meeting. |
Naam | STALMANS |
Initialen | I |
Instituut | UZ Leuven |
Stad | Leuven |
Naam | Berdeaux |
Initialen | G |
Instituut | IMS HEOR |
Stad | Vilvoorde |
Naam | Boons |
Initialen | S |
Instituut | UZ Leuven |
Stad | Leuven |
Naam | Vandewalle |
Initialen | E |
Instituut | UZ Leuven |
Stad | Leuven |