View abstract

This abstract is assigned to session AOB Free Papers 1

Presentation type	Oral presentation
Title	Therapeutic Drug Monitoring of Adalimumab in Paediatric non-infectious Uveitis: A Retrospective Analysis

Purpose	To evaluate the use of therapeutic drug monitoring (TDM) of adalimumab in children with chronic non-infectious uveitis (NIU).
Methods	Children with chronic NIU diagnosed under the age of 16, treated with adalimumab, with (group 1) or without (group 2) concomitant immunomodulating treatment (IMT), with at least one available serum adalimumab trough level (TL) and anti-adalimumab antibody (AAA) level were included in this retrospective cohort study. Controlled uveitis was defined as an anterior chamber activity ≤0.5 cells on ≤2 steroid eye drops per day.
Results	A total of 37 children (73 eyes) treated with adalimumab for NIU were included (median age, 7.4 years; range, 2.2–13.8). During a median duration of 29 months (range 5-79), 200 TL were measured, with a median concentration of 13.4 µg/ml (range 0–33), and TDM-based therapeutic adjustments were performed in 22 patients (59.5%). In group 1 (n=28), treatment was escalated in 9 patients (32.1%), resulting in increased adalimumab levels (median +4.1 µg/ml, range [-0.7; +15.6]) in 7 patients (87.5%), and regained uveitis control in 5 of 8 patients (62.5%). In group 2 (n=9), 4 patients developed primary treatment failure, with TL <0.5 µg/ml and elevated AAA levels. In 3 of the remaining 5 patients, treatment adjustments (both escalation and taper) were made.
Conclusion	TDM of adalimumab is a promising tool to optimise the clinical outcome and limit treatment related side effects in pediatric uveitis.
Conflict of interest	No

Authors 1

Last name	PARK
Initials	C
Department	Dpt of Ophthalmology (Ghent UH)
City	Ghent

Authors 2

Last name	BONROY
Initials	C
Department	Dpt of Clinical Biology (Ghent UH)
City	Ghent

Authors 3

Last name	DEHOORNE
Initials	JL
Department	Dpt of Pediatric Rheumatology (Ghent UH)
City	Ghent

Authors 4

Last name	KREPS
Initials	EO
Department	Dpt of Ophthalmology (Ghent UH)
City	Ghent