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Presentation type	E-poster
Title	Bilateral diffuse uveal melanocytic proliferation (BDUMP) revealing lung adenocarcinoma

Purpose	To report BDUMP as the presenting sign of an occult lung adenocarcinoma and highlight the contribution of multimodal ocular imaging and plasma exchange.
Methods	A 67-year-old man presented with a 3-week history of painless bilateral visual loss. Complete ophthalmic examination, OCT, fluorescein angiography and B-scan ultrasonography were performed. Systemic staging included contrast-enhanced CT, brain MRI, PET-CT and nodal sampling.
Results	Right eye (RE) visual acuity was 16/20 and counting fingers in the left eye (LE). Bilateral pigmented vitreous cells, multifocal uveal melanocytic lesions, serous retinal detachments (SRDs) and outer-retinal irregularities were observed, as well as an iris naevus-like lesion in the RE. Fluorescein angiography showed typical reticular early hyperfluorescent orange-red subretinal patches with retinal pigment epithelium atrophy. Urgent systemic work-up disclosed a pleura-contacting right lower-lobe mass with mediastinal nodal involvement; pathology confirmed poorly differentiated lung adenocarcinoma. After five plasma-exchange sessions, subretinal fluid regressed in LE and visual acuity improved to 2/20, although RE visual acuity deteriorated due to the migration of SRDs toward the subfoveal region.
Conclusion	BDUMP may be the first manifestation of an otherwise occult malignancy and should prompt urgent systemic investigation. Multimodal imaging is pivotal for distinguishing this paraneoplastic syndrome from uveal melanoma and other causes of bilateral serous detachment. While outcomes remain variable, early plasma exchange may be the only opportunity for anatomical and functional improvement in selected cases, alongside treatment of the underlying cancer.
Conflict of interest	No

Authors 1

Last name	EL KORTOBI
Initials	S
Department	CUSL
City	Brussels

Authors 2

Last name	BUGHIN
Initials	A
Department	CUSL
City	Brussels

Authors 3

Last name	GUESSOUS
Initials	Y
Department	CUSL
City	Brussels

Authors 4

Last name	BARTOSZEK
Initials	P
Department	CUSL
City	Brussels

Authors 5

Last name	KOZYREFF
Initials	A
Department	CUSL
City	Brussels