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This abstract is assigned to session AOB Free Papers 1

Presentation type	Oral presentation
Title	Oculomotor Phenotyping for Neurological and Neuromuscular Dysfunction

Purpose	This study evaluates the potential of video-oculography (VOG) as a diagnostic tool in neurological and ocular disorders by reviewing literature findings and assessing their clinical applicability using the neuroClues device. Focus is placed on myasthenia gravis (MG), Parkinson’s disease (PD), progressive supranuclear palsy (PSP), and differentiation between restrictive and paretic oculomotor disorders compared to healthy controls.
Methods	Relevant literature on VOG parameters, including saccades, smooth pursuit and optokinetic nystagmus, was reviewed. Subsequently a clinical protocol was developed to evaluate these specific oculomotor patterns using the neuroClues device.
Results	An overview is provided of the main oculomotor patterns observed in each condition and their comparison with healthy controls. The established theoretical parameters such as reduced vertical saccadic velocity in PSP and the saccadic fatigue in MG are currently being mapped against real measurements using the neuroClues device. The study protocol and technical validation have been finalized and preliminary clinical data collection is underway to verify the literature-derived algorithms. Attention will be given to the clinical significance and to applications of VOG, including recognition, treatment monitoring and longitudinal follow-up with emphasis on clinical ophthalmology.
Conclusion	VOG may offer a valuable approach for the assessment of neurological and ocular disorders, including MG, PD, PSP and distinction between restrictive and paretic oculomotor pathology. By bridging concrete literature findings with the clinical application of the neuroClues device this project aims to support enhanced objective clinical evaluation.
Conflict of interest	No

Authors 1

Last name	ROSELETH
Initials	L
Department	Department of Ophthalmology, University Hospital Leuven
City	Leuven

Authors 2

Last name	CASSIMAN
Initials	C
Department	UZ Leuven
City	Leuven