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Presentation type	E-poster
Title	Chromosomal difficienties and gene mutations in uveal melanoma

Purpose	retrospective study on the results of genetic testing in uveal melanoma patients
Methods	retrospective study in 700 uveal melanoma patients.
Results	In 296 uveal melanoma patient a biopsy was taken. Chromosomal evaluation was effectively done in 159 patients and mutation testing with Next Generation Sequencing (NGS) was done in 214 patients. In 87 patients monosmy 3 was found (54%), and in 68 patients deviation in the chromosome 8 were found. NGS schowed a BAP mutation on the tumor tissue in 52 of 188 patients (28%). In 28% a GNAQ mutation was found, and in 25% a GNA11 mutation. Other mutations were IDH2, APC, KRAX, HRAS, NFI mutation in < 1% of patients.
Conclusion	Biopsies can give in an increasing amount of cases a result on the genetic modifications of uveal melanoma. This can help in the determination of prognosis and future immunotherapy
Conflict of interest	No

Authors 1

Initials	G
Last name	Missotten
Department	UZLeuven - Jessa ziekenhuis Hasselt
City	Leuven - Hasselt

Authors 2

Initials	D
Last name	Thal
Department	UZLeuven - Pathology
City	Leuven

Authors 3

Initials	I
Last name	De Clerck
Department	UZLeuven
City	Leuven

Authors 4

Initials	J
Last name	Van Calster
Department	UZLeuven
City	Leuven

Authors 5

Initials	I
Last name	Van den Bempt
Department	UZLeuven - Clinical laboratory
City	Leuven