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This abstract is assigned to session AOB Free Papers 2

Presentation type	Oral presentation
Title	Comparative study of PRESERFLOTM MicroShunt, XEN45® Gel Stent and Trabeculectomy in open-angle glaucoma

Purpose	To compare the safety and efficacy of PRESERFLOTM MicroShunt (MS), trabeculectomy (Trab) and XEN45® Gel Stent (XEN) in patients with open-angle glaucoma during the first year.
Methods	A single-centre retrospective case-control study was conducted on all eyes that underwent standalone glaucoma surgery between 2013 and 2020. The primary outcome was surgical success after 1 year. Complete success was defined as intraocular pressure (IOP) of 6–15 mmHg or 6–18 mmHg, without vision loss, additional glaucoma surgery, or IOP-lowering medication. Qualified success allowed medication and/or laser therapy. Secondary outcomes included visual acuity, medication use, and complications.
Results	In total, 384 eyes of 384 patients were included, 82 eyes received a MS, 117 a Trab and 185 a XEN. MS achieved the highest rates of both complete and qualified success across both IOP criteria. Regarding complete success, MS was equal to Trab (p=0.207, IOP 6-15mmHg and p=0.230, IOP 6-18). MS (p<0,001) and Trab (p=0.030 and p=0.018, respectively) performed significantly better than XEN. For qualified success, MS showed superior outcomes, with statistical significance only observed comparing MS to XEN in the IOP 6-18 mmHg group (p=0.049). Significant hypotony was rare across groups and peaked in the first week. Minor interventions were more frequent after Trab.
Conclusion	MS and Trab achieved comparable success rates and outperformed XEN without use of medication. MS demonstrated superior efficacy over XEN regardless of medication use. MS and Xen need fewer post-operative interventions compared to Trab.
Conflict of interest	Yes
Details of conflicting interests	I. S. received a research grant from AbbVie and Santen.

Authors 1

Initials	MI
Last name	Billen
Department	UZL/KUL
City	Leuven

Authors 2

Initials	T
Last name	Jacobs
Department	UZL/KUL
City	Leuven

Authors 3

Initials	J
Last name	Van Eijgen
Department	UZL/KUL
City	Leuven

Authors 4

Initials	S
Last name	Lemmens
Department	UZL/KUL
City	Leuven

Authors 5

Initials	E
Last name	Vandewalle
Department	UZL/KUL
City	Leuven

Authors 6

Initials	I
Last name	Stalmans
Department	UZL/KUL
City	Leuven