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Presentation type	E-poster
Title	Conjunctival TFG::ROS1 fusion positive inflammatory myofibroblastic tumor treated with crizotinib

Purpose	To describe the clinical course and management of a conjunctival inflammatory myofibroblastic tumor with a TFG::ROS1 fusion in a 33-year-old woman presenting with a progressively enlarging subconjunctival mass.
Methods	Diagnosis was confirmed by biopsy and RNA next-generation sequencing.
Results	Treatment with the tyrosine kinase inhibitor crizotinib led to complete tumor resolution, however therapy was discontinued due to a sarcoid-like granulomatous reaction. Visual acuity remained stable at 20/20 throughout, and no recurrence was observed.
Conclusion	This case highlights the diagnostic challenges of conjunctival inflammatory myofibroblastic tumor, the therapeutic potential of targeted kinase inhibition, and the critical role of genomic profiling in guiding personalized treatment for rare ocular tumors such as inflammatory myofibroblastic tumor.
Conflict of interest	No

Authors 1

Initials	L
Last name	Bourdeaud'huy
Department	Universiteit Gent
City	Gent

Authors 2

Initials	D
Last name	Roels
Department	UZ Gent
City	Gent