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Presentation type	E-poster
Title	Comparison of Scheimpflug Corneal Tomography and Anterior Segment Optical Coherence Tomography measurements in Corneal Cystinosis

Purpose	To report the clinical course and compare the utility of Scheimpflug tomography (ST) and Anterior Segment Optical Coherence Tomography (AS-OCT) for central corneal thickness (CCT) and corneal densitometry (CD) assessment in patients with corneal crystals due to nephropathic cystinosis.
Methods	A retrospective chart analysis of 3 patients with nephropathic cystinosis, and the presence of corneal cystine crystals in both eyes was performed. All patients underwent clinical examination, as well as anterior segment photography, ST (Pentacam HR), and AS-OCT (CASIA2) scans. CD was exported from built-in proprietary software for ST and from custom-made validated software for AS-OCT. AS-OCT images were rescaled to grayscale units from 0 (maximum transparency) to 100 (minimum transparency) to match built-in ST densitometry readings. Further, the mean pixel intensity, representative of CD, was calculated from the pixels corresponding to the segmented cornea.
Results	All three patients had pathognomonic cystine crystals deposits in the cornea and were treated with cysteamine medications that resulted in clinical improvement. Both examinations could be performed but in the more severe cases, AS-OCT showed far greater utility to estimate CD. In four out of six eyes examined, ST showed disproportionate CCT values, compared to the AS-OCT, while reliable CD measurements were only available in AS-OCT.
Conclusion	The AS-OCT should be considered a baseline ocular measurement in cystinosis and in the evaluation of disease progression and treatment efficacy.
Conflict of interest	No

Authors 1

Last name	VERCAUTEREN
Initials	L
Department	Antwerp University Hospital
City	Antwerp

Authors 2

Last name	Consejo
Initials	A
Department	University of Zaragoza
City	Zaragoza

Authors 3

Last name	De Vries
Initials	MJ
Department	Antwerp University Hospital
City	Antwerp

Authors 4

Last name	Krolo
Initials	I
Department	University Hospital Brussels
City	Brussels

Authors 5

Last name	Koppen
Initials	C
Department	Antwerp University Hospital
City	Antwerp

Authors 6

Last name	Ni Dhubhghaill
Initials	S
Department	University Hospital Brussels
City	Brussels