View abstract

This abstract is assigned to sessions

Presentation type	E-poster
Title	Acute macular neuroretinopathy following SARS-CoV-2 vaccination.

Purpose	To describe a patient who presented with bilateral paracentral scotoma shortly after receiving the first dose of vaccine against severe acute respiratory syndrome – coronavirus-2 (SARS-CoV-2).
Methods	Observational case report.
Results	A 21-year-old Caucasian woman, on oral anticonceptives, presented with sudden-onset, bilateral, paracentral scotoma two days following her first intramuscular dose of the AstraZeneca Vaxzevria ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2. Her ophthalmic and general history were unremarkable. Dilated fundoscopy showed faint, red brown perifoveal lesions in both eyes, which were particularly highlighted on near-infrared reflectance (NIR) imaging. On spectral-domain optical coherence tomography (SD-OCT), a disruption in the inner/outer segment (IS/OS) junction was visible in the region of the petaloid lesions, as well as a thickened outer plexiform layer. These features on multimodel imaging were consistent with acute macular neuroretinopathy (AMN).
Conclusion	We describe a case of AMN occurring shortly after administration of the first first dose of the ChAdOx1 nCoV-19 vaccine. This association may indicate an immune-mediated pathway, however, the exact mechanism remains elusive.
Conflict of interest	No

Authors 1

Last name	OSAER
Initials	M
Department	UZ Gent
City	Gent

Authors 2

Last name	De Zaeytijd
Initials	J
Department	UZ Gent
City	Gent

Authors 3

Last name	Leroy
Initials	BP
Department	UZ Gent
City	Gent

Authors 4

Last name	Kreps
Initials	E
Department	UZ Gent
City	Gent