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Title

Clinical impact of 18F-FDG PET CT in the work up of children with uveitis.

Purpose	To evaluate the usefulness of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) in the work up of paediatric uveitis.
Methods	We performed a retrospective study of 12 children followed for uveitis who underwent whole body 18F-FDG PET/ultra low dose CT between 2011 and 2019.
Results	The average patients’ age was 11 years. 100% of patients presented bilateral uveitis, 50% panuveitis and 92% (11/12) had choroidal involvement. 5 of the 12 (42%) patients showed abnormal 18F-FDG uptake on their 18F-FDG PET/CT, including 3 with pathognomonic images of active granulomatous diseases. A biopsy was performed in one of these patients (consistent with sarcoidosis) and in the two others with abnormal 18F-FDG uptake without pathognomonic images of granulomatous disease (one consistent with sarcoidosis, the other negative). Final uveitis diagnosis were idiopathic in 58% of the patients, ocular sarcoidosis in 17% (2/12), TINU in 16,6% (2/12) and tubercular uveitis in 8,3% (1/12).
Conclusion	In this small series, 18F-FDG PET/CT provided important information for uveitis diagnosis in approximatively 30 % (4/12) of our patients. Further studies are needed to define the exact place of 18F-FDG PET/CT and chest CT in the work-up of paediatric uveitis.
Conflict of interest	No

Authors 1

Last name	EL MOUDEN
Initials	J
Department	Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB
City	Bruxelles

Authors 2

Last name	Bazewicz
Initials	M
Department	Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB
City	Bruxelles

Authors 3

Last name	Makhoul
Initials	D
Department	Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB
City	Bruxelles

Authors 4

Last name	Goffin
Initials	L
Department	Pediatric Immuno-Rheumatology - CHU HUDERF - ULB
City	Bruxelles

Authors 5

Last name	Judice
Initials	L
Department	Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB
City	Bruxelles

Authors 6

Last name	Caspers
Initials	L
Department	Ophthalmology - CHU St-Pierre - ULB
City	Bruxelles

Authors 7

Last name	Draganova
Initials	D
Department	Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB
City	Bruxelles

Authors 8

Last name	Garcia
Initials	C
Department	Nuclear Medicine - CHU St-Pierre - ULB
City	Bruxelles

Authors 9

Last name	Willermain
Initials	F
Department	Ophthalmology - CHU St-Pierre and CHU Brugmann - ULB
City	Bruxelles