Title | Risk factors for growth of choroidal nevi with a juxtapapillary location in 90 consecutive patients |
Abstract Nr. | 3008 |
Purpose | To define the real incidence of tumor growth of juxtapapillary choroidal nevi and the clinical and ultrasonographic risk factors predictive of their growth. |
Methods | This retrospective case series included 90 juxtapapillary nevi (located at < 500 µm to disc) with no other risk factor for growth such as orange pigment, subretinal fluid, thickness greater than 2mm or tumor-related visual symptoms (known as TFSOM) at initial visit. The patients were followed since December 1997 till July 2017 with a mean follow-up of 83 months (range: 6-215). |
Results | The mean age at diagnosis was 62 years. The mean largest tumor diameter was 3.5mm (range: 0.5-10) and tumor thickness 1.6mm (range: 1-2). Lesion growth was observed in 2 of the 90 nevi (2%) after 81 months for the first one, treated subsequently with transpupillary thermotherapy (TTT), and after 82 months for the second one, treated subsequently with TTT and Iodine-125 plaque. No patient developed metastatic disease. Due to the small number of events, statistical analyses did not allow us to find predictive factors for tumor growth in our series. |
Conclusion | Among posterior uveal melanocytic lesions with a juxtapapillary location and no other factor predictive of growth such as orange pigment, subretinal fluid, thickness greater than 2mm or tumor-related visual symptoms, the incidence of tumor growth was reported to be 2% in our series. The juxtapapillary location appeared to carry a lower risk for malignant transformation than the other known risk factors. |
Conflict of interest | No |
Last name | RAMARD |
Initials | H |
Department | Cliniques Universitaires St Luc |
City | Brussels |
Last name | Bartoszek |
Initials | P |
Department | Cliniques Universitaires St Luc |
City | Brussels |
Last name | De Potter |
Initials | P |
Department | Cliniques Universitaires St Luc |
City | Brussels |