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Title	The vitreopapillary interface in healthy and glaucoma: evolution of posterior vitreous detachment in the VPI study.
Abstract Nr.	1046

Purpose	To investigate the vitreopapillary interface (VPI) in healthy and glaucoma according to the different stages of posterior vitreous detachment (PVD) formation.
Methods	Single center cross-sectional case-control study including healthy subjects and glaucoma patients. Posterior vitreous detachment (PVD) stage was assessed with spectral domain optical coherence tomography (SD-OCT). Glaucoma patients additionally had a comprehensive ophthalmological investigation including measurement of visual acuity, intraocular pressure, refractive status and automated perimetry.
Results	Data on 582 subjects (1091 eyes) was included in this study (493 eyes of 258 healthy subjects and 598 eyes of 324 glaucoma patients). For every PVD stage, glaucoma patients were significantly older than their healthy counterparts (PVD stage 0: 49.6 (±13.7) vs 57.52 (±8.9), stage 1: 54.6 (±13.9) vs 65.3 (±8.3), stage 3: 67.7 (±5.9) vs 73.3 (±8.1) and stage 4: 71.4 (±9.4) vs 74.9 (±9.4) years, respectively). Defining the eye with the highest PVD stage as index eye, the majority of the study subjects (72.4%) shows the same PVD stage in the contralateral eye.
Conclusion	The VPI study is a large clinical trial investigating the vitreopapillary interface in healthy and glaucoma. Glaucoma patients experience all stages of PVD formation at an older age in respect to healthy subjects.
Conflict of interest	No

Authors 1

Last name	WILLEKENS
Initials	K
Department	UZ Leuven
City	Leuven

Authors 2

Last name	Pinto
Initials	LA
Department	Centro hospital Lisboa Norte
City	Lissabon

Authors 3

Last name	Lemmens
Initials	S
Department	UZ Leuven
City	Leuven

Authors 4

Last name	Bataillie
Initials	S
Department	UZ Leuven
City	Leuven

Authors 5

Last name	Somers
Initials	A
Department	UZ Leuven
City	Leuven

Authors 6

Last name	Vandewalle
Initials	E
Department	UZ Leuven
City	Leuven

Authors 7

Last name	Stalmans
Initials	P
Department	UZ Leuven
City	Leuven

Authors 8

Last name	Stalmans
Initials	I
Department	UZ Leuven
City	Leuven