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This abstract is assigned to session AOB Poster session 2 - Inflammatory pathology – Anterior segment – Ophthalmogenetics - Miscellaneous

Title	Episcleritis in hypocomplementemic urticarial vasculitis syndrome: a case
Abstract Nr.	2026

Purpose	To report a case of episcleritis in hypocomplementemic urticarial vasculitis syndrome (HUVS).
Methods	A 56-year-old Caucasian woman presented with bilateral episcleritis. She underwent a complete ophthalmological and systemic work-up.
Results	She presented with episodes of bilateral redness since more than 20 years ago. She had a history of skin lesions, arthritis and glomerulonephritis. Biomicroscopy showed bilateral episcleritis. In 1981 she reported a first episode of non-pruritic, urticarial wheals on both hands, migrating to the whole body, but sparing the face. Biopsy showed neutrophilic dermatitis without necrotising vasculitis. She developed episodes of arthritis, angioedema, abdominal pain and glomerulonephritis. Renal biopsy showed proliferative glomerulonephritis with mesangial deposition of C3 and C1q and subintimal deposition of C3, C1q and IgM. Laboratory results showed reduced C3, CH50 and C4. C1q complexes were positive. ANA, anti-dsDNA, anti-ENA and RF were negative. ESR was elevated. CBC renal and hepatic function were within normal limits. Protein analysis was normal. A diagnosis of HUVS was made on the basis of two major and five minor criteria.
Conclusion	Episcleritis, conjunctivitis and rarely uveitis may be observed in HUVS. Although HUVS is relatively rare, it should be included in the differential diagnosis of these conditions. Awareness of HUVS and rational diagnostic evaluation will prevent misdiagnosis.
Conflict of interest	No

Authors 1

Last name	POTVIN
Initials	A
Department	Medical School, Ghent University, Belgium
City	Ghent

Authors 2

Last name	MAES
Initials	B
Department	Department of Nephrology, AZ Delta, Belgium
City	Roeselare

Authors 3

Last name	VAN DORPE
Initials	J
Department	Department of Pathophysiology, Ghent University Hospital, Belgium
City	Ghent

Authors 4

Last name	LEROY
Initials	BP
Department	Department of Ophthalmology, Ghent University Hospital, Belgium
City	Ghent

Authors 5

Last name	DE SCHRYVER
Initials	I
Department	Department of Ophthalmology, Ghent University Hospital, Belgium
City	Ghent