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Title	Ocriplasmin is particularly efficacious in specific types of vitreomacular traction and can induce transient ultrastructural changes at the optic disc
Abstract Nr.	1065

Purpose	To determine the efficacy and safety of ocriplasmin for vitreomacular traction (VMT) release in specific indications, and to study changes in optic disc and peripapillary region.
Methods	Retrospective, single-center, observational case series. In 38 eyes with VMT (of which 10 had concomitant MH), determined by optical coherence tomography (OCT), a single intravitreal injection of ocriplasmin was administered. Baseline characteristics included age, gender, presence of epiretinal membrane (ERM) and/or macular hole (MH), and visual acuity. Spectral domain OCT and Heidelberg retinal tomography (HRT) were performed at baseline and during follow-up visits.
Results	A total of 71.1% (27/38) eyes [37 patients] treated with ocriplasmin had VMT resolution with 40% (4/10) of eyes with MH at baseline (10/38) achieving MH closure. 90% (9/10) of eyes with MH at baseline showed VMT release. 36.8% (14/38) had increased subretinal fluid (SRF) that resolved concurrently with posterior vitreous detachment (PVD) in 12 patients, with partial PVD in 1 patient, and no PVD in the latter. There was also SRF accumulation in the peripapillary region in 21.4% (3/14) of patients with SRF in the macular region that largely resolved spontaneously by 1 month
Conclusion	Ocriplasmin is a novel treatment for patients with VMT. Careful patient selection can improve ocriplasmin efficacy and will aid clinical decision making. Transient optic disc changes after its use are possible.

Authors 1

Last name	WILLEKENS
Initials	KW
Department	UZ Leuven - Dpt Oftalmologie
City	Leuven

Authors 2

Last name	Abegão Pinto
Initials	LAP
Department	Institute of Pharmacology and Neurosciences, Faculty of Medicine of Lisbon University, Lisbon, Portu
City	Lisbon

Authors 3

Last name	Vandewalle
Initials	EV
Department	UZ Leuven
City	Leuven

Authors 4

Last name	Stalmans
Initials	IS
Department	UZ Leuven
City	Leuven

Authors 5

Last name	Stalmans
Initials	PS
Department	UZ Leuven
City	Leuven