Title | Efficacy and tolerability of bimatoprost 0.1 mg/ml (Lumigan®) in POAG/OHT in routine clinical practice in Belgium |
Abstract Nr. | P119 |
Purpose | Observational study to assess the efficacy, tolerability and persistence of use of bimatoprost 0.1 mg/ml in patients with POAG or OHT) in routine clinical practice. |
Methods | Patients with POAG or OHT prescribed bimatoprost 0.1 mg/ml were enrolled. Disease characteristics and prior treatments were collected at baseline. Intraocular pressure (IOP), adverse events (AEs) and discontinuations were recorded prospectively. Data were analysed descriptively |
Results | A total of 933 patients from 117 centres in Belgium were included; median age 65.8 years and 51% females. Most patients had POAG (64%) and 52% of patients had previously received IOP-lowering medication. The median duration of therapy was 8.9 weeks. Mean IOP was reduced from baseline to final visit by 23% in both eyes: by -5.1 mmHg in the right eye (from 22.0 to 16.9 mmHg) and by -5.0 mmHg in the left eye (from 22.0 to 17.0 mmHg). According to physician evaluation, target IOP was reached or even lower in 75.9% of patients and tolerability was very good or good in 87.9% of patients. The majority of patients (80.9%) indicated they would continue bimatoprost beyond the end of the study. AEs were reported in 142 patients (15.2%). Only hyperaemia (7.6%), eye irritation (2.7%) and eye pain (1.5%) occurred in >1% of patients. |
Conclusion | Bimatoprost 0.1 mg/ml can produce additional IOP-lowering in routine clinical practice in patients with POAG or OHT who have had prior therapy, as well as reducing IOP in previously-untreated patients. Bimatoprost 0.1 mg/ml was well tolerated and effective and was associated with a high rate of continuation of therapy. |
Last name | STEVENS |
Initials | AM |
Department | Dept Ophthalmology University Clinic |
City | Ghent |
Last name | Hondegem |
Initials | K |
Department | Middelheimziekenhuis Ophtalmologie |
City | Antwerpen |
Last name | Deghislage |
Initials | C |
Department | Ziekenhuis Oost-Limburg Oogziekten |
City | Genk |
Last name | Morgan-Warren |
Initials | R |
Department | Allergan UK |
Last name | Leaback |
Initials | R |
Department | Allergan UK |